investigator_user investigator user funding collaborators pending menu bell message arrow_up arrow_down filter layers globe marker add arrow close download edit facebook info linkedin minus plus save share search sort twitter remove user-plus user-minus
  • Project leads
  • Collaborators

Bone Microenvironment on Dormancy of Metastatic Prostate Cancer Cells

Sue-Hwa Lin

2 Collaborator(s)

Funding source

University of Texas MD Anderson Cancer Center
The majority of men who succumb to prostate cancer (PCa) die of bone metastasis. Bone metastasis can occur years or decades after prostectomy, due to reactivation of disseminated tumor cells (DTCs) that had been dormant at the metastatic site in bone. Because treatments for bone metastasis have so far only achieved short-term disease control with excessive toxicity, preventing the tumor cells from exiting dormancy will be an innovative treatment approach, especially in PCa that occurs in the aging male population. Thus, it is critical to identify the mechanisms by which tumors enter/exit dormancy. Metastasis is attributed to properties of the tumor cells (seed) and their interaction with the microenvironment of the metastasized organs (soil). It is possible that microenvironment signaling in bone regulates the switch between proliferation and dormancy.

Related projects