This is a proposal for a multi-institutional MIDAS Center of Excellence called the Center for Statistics andQuantitative Infectious Diseases (CSQUID). The mission the Center is to provide national and internationalleadership. The lead institution is the Fred Hutchinson Cancer Research Center (FHCRC). Otherparticipating institutions are the University of Florida, Northeastern University, University of Michigan, EmoryUniversity, University of Washington (UW), University of Georgia, and Duke University. The proposalincludes four synergistic research projects (RP) that will develop cutting-edge methodologies applied tosolving epidemiologic, immunologic and evolutionary problems important for public health policy in influenza,dengue, polio, TB, and other infectious agents: RP1: Modeling, Spatial, Statistics (Lead: I. Longini, UFlorida); RP2: Dynamic Inference (Lead: P. Rohani, U Michigan); RP 3: Understanding transmission withintegrated genetic and epidemiologic inference (Co-Leads: E. Kenah, U Florida and T. Bedford, FHCRC); RP4: Dynamics and Evolution of Influenza Strain Variation (Lead: R. Antia, Emory U). The SoftwareDevelopment and Core Facilities (Lead: A. Vespignani, Northeastern U) will provide leadership in softwaredevelopment, access, and communication. The Policy Studies (Lead: J. Koopman, U Michigan) will provideleadership in communication of our research results to policy makers, as well as conducting novel researchinto policy making. The Training, Outreach, and Diversity Plans include ongoing training of 9 postdoctoralfellows and 5.25 predoctoral research assistants each year, support for participants in the Summer Institutefor Statistics and Modeling in Infectious Diseases (UW) and ongoing Research Experience forUndergraduates programs at two institutions, among others. All participating institutions and the Center arecommitted to increasing diversity at all levels. Center-wide activities include Career Development Awards forjunior faculty, annual workshops and symposia, outside speakers, and participation in the MIDAS Networkmeetings. Scientific leadership will be provided by the Center Director, a Leadership Committee, an externalScientific Advisory Board as well as the MIDAS Steering Committee.