This National Biomedical Resource Center at the Brigham & Women's Hospital provides a unique, Centralized infrastructure for translational research in the area of image-guided therapy. The multidisciplinary program involves clinical investigators, biomedical engineers, and basic scientists in promoting and advancing IGT methods and related innovative clinical applications. We develop and make available new, clinically relevant technologies in six discrete TRD Core Projects: 1) Computational Core; 2) Imaging Core; 3) Image-Guidance Core; 4) Neurosurgery Core; 5) Prostate Core and 6) Focused Ultrasound Therapy Core. Our goal is to combine current advances in the field of imaging (like Molecular Imaging, Functional and Metabolic Imaging) with advanced therapies (like MRI-guided Focused Ultrasound ablation or targeted drug delivery, endoscopic surgery or robotics) to achieve less invasive, safer and more effective therapeutic options.