Blood cells called phagocytes are key components of the immune system; however, when dysregulated, they contribute to inflammatory and autoimmune diseases as well as cancer. My research program is focused on identifying genes and regulatory pathways governing the development and activity of phagocytes, to better understand and manipulate them in an effort to control disease. My laboratory uses models of lupus, inflammatory bowel disease, breast cancer and colitis-associated cancer, which mimic the complex physiology observed in human diseases. Our aim is to translate our improving understanding of phagocyte biochemistry into strategies to control autoimmunity, chronic inflammation or elicit anti-tumour immunity.