NCI researchers are launching a pilot study of head and neck cancer precursors in Taiwan. The goals of the pilot study are: 1) to pilot the study procedures, including recruitment and follow-up of participants, collection of questionnaire data, and collection, storage, and testing of biologic specimens and 2) to collect preliminary data, such as prevalence of risk factors and histologic precursors, to aid in the design of a cohort study. The cohort study is aimed at investigating the early natural history of head and neck cancer precursor lesions. Specifically, the cohort study will address rates of progression and regression of head and neck cancer precursors and epidemiologic and molecular predictors of progression/regression.